A Clinical Case Report of Cribriform-Morular Variant of Papillary Thyroid Carcinoma with Neuroendocrine Differentiation and Aggressive Behaviour in a Patient with Familial Adenomatous Polyposis Coli
نویسندگان
چکیده
Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) is a rare variant of papillary thyroid cancer mostly occurring in young females under the age of 30. CMVPTC is associated with familial adenomatous polyposis coli and has an excellent prognosis with most patients surviving upwards of 20 years. We describe the clinical course of an aggressive variant of CMVPTC in a 42-year-old male with the first known reported features of neuroendocrine differentiation (the unusual histological features are published elsewhere in a separate article (Cameselle Teijeiro, J., et al. Am. J. Clin. Pathol., 131:134-142, 2009). The patient survived just 23 months from diagnosis and we outline our management here including the use of radiolabelled Yttrium 90 therapy.
منابع مشابه
Cribriform-Morular Variant of Papillary Carcinoma: Association with Familial Adenomatous Polyposis - Report of Three Cases and Review of Literature
We describe a rare variant of papillary thyroid carcinoma (PTC), the Cribriform-Morular Variant (C-MV). A handful of cases have been described in the literature of this entity. They exhibit the morphologic features of a distinctive papillary neoplasm along with solid, cribriform, and squamoid-morular areas. The cribriform and morular features make this a separate entity which could be mistaken ...
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We describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy. The angioinvasive neoplasm combined a mixture of trabecular, solid, cribriform, and follicular patterns of growth with CD10+ morules. Follicles were devo...
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Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare tumor, which exceptionally occurs at pediatric age. CMV-PTC may develop in patients with familial adenomatous polyposis (FAP) or may be a sporadic tumor. The authors present a case of CMV-PTC in a 10-year-old girl patient without FAP history, who presented with a left neck mass. The patient underwent total thyroidecto...
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Papillary thyroid carcinoma (PTC) associated with familial adenomatous polyposis (FAP) is rare. It is usually associated with the cribriform-morular variant of PTC, with unusual patterns on detailed histology examination. This variant is known to have a good prognosis. Papillary thyroid carcinoma associated with FAP commonly occurs in females in their 30s and rarely in the elderly. We report a ...
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It has been well established in the literature that the cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) has been observed with higher frequency in familial adenomatous polyposis (FAP) patients. In the usual setting, patients with FAP are identified based on their germline mutations and the diagnosis of thyroid neoplasm is made after the FAP diagnosis. We herein report a case ...
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